| 摘要 |
Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1: wherein: R1 and R2, which are identical or different, are each hydrogen, C1-C6-alkyl, C1-C6-alkyloxy, OH, F, Cl, or Br; R3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy; R4 and R5, which are identical or different, are each hydrogen, methyl, or ethyl; R6 is hydrogen; X is NH2, NH-(C1-C6-alkyl), N(C1-C6-alkyl)2, the two C1-C6-alkyl groups of which are identical or different, NH-COH, NH-CO(C1-C6-alkyl), or F; A is -(CH2)3-, -CH2-CH2-O-, -CH2-O-CH2-, -(CH2)4-, -CH(C1-C6-allyl)-O-CH2-, -(CH2)2-O-CH2-, -(CH2)3-O-, -(CH2)5-, -CH2-O-(CH2)3-, -(CH2)2-O-(CH2)2-, -(CH2)3-O-CH2-, -(CH2)4-O-, -CH2-O-CH2-CH2-O-, the racemates thereof, the enantiomers thereof, the diastereomers thereof, and mixtures thereof, and the pharmacologically acceptable acid addition salts thereof, processes for preparing them, and their use as pharmaceutical compositions.
|
