5-HT6 Receptor antagonist medicaments, useful for treating central nervous system disorders such as Alzheimer's disease, comprising naphthalene N-phenylsulfonamide derivatives

摘要

The use of alkyl, heteroaryl or heterocyclyl-substituted naphthalene N-phenylsulfonamide derivatives (I) as medicaments having 5-HT6 receptor antagonist activity is new. The use of sulfonamides of formula (I) or their salts is claimed in the production of medicaments for the prophylaxis and/or treatment of diseases treatable with 5-HT6 receptor antagonists. R1 = 1-6C alkyl, substituted by 1-3 of OH, SO2T, (6-10C) aryl-(1-5C) alkylamino, 5-10 membered heteroarylamino (optionally substituted by 1-3 of T, COOT or NO2), mono- or di-(3-7C cycloalkyl)-amino, piperidino, morpholino, N-(R4)-piperazino or thiamorpholino; 5-10 membered heteroarylamino (optionally substituted by 1-3 of T, COOT or NO2); or a heterocyclic group of formula (a); R4 = T, 1-5C alkanoyl or COOT, where T, 1-3C alkanoyl or COOT as values of R4 are optionally substituted by 1 or 2 OH; n = 0 or 1; Y = O, NR4 or S; dotted line in (a) = optional bond; R2 = H, 1-6C alkanoyl (optionally substituted by 1-3 halo), 3-7C cycloalkylcarbonyl or 6-10C arylcarbonyl; R3 = -NHCOR5 or -CONHR5; R5 = 1-6C alkyl (optionally substituted by 1-3 of halo, OH or OCOT) or 3-7C cycloalkyl (os by 1 or 2 T); T = 1-4C alkyl.