发明名称 |
Pamidronate solution |
摘要 |
A stable injectable solution containing pamidronate and a method for preparing a therapeutic aqueous disodium pamidronate solution. The method comprises preparing a slurry of pamidronic acid in water, combining aqueous sodium hydroxide with the slurry in an amount about 2:1 molar ratio of sodium hydroxide to pamidronic acid to yield a solution of disodium pamidronate having visual clarity and a pH of about 6.5, and packaging the solution in sealed containers. A unit dosage form including the solution and a vial or ampule comprising the unit dosage form are also described.
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申请公布号 |
US2002058647(A1) |
申请公布日期 |
2002.05.16 |
申请号 |
US20010773480 |
申请日期 |
2001.02.02 |
申请人 |
HANDRECK GREGORY PAUL;ZHOU WEI;TAIT RUSSELL JOHN |
发明人 |
HANDRECK GREGORY PAUL;ZHOU WEI;TAIT RUSSELL JOHN |
分类号 |
A61K9/00;A61K31/663;A61K47/02;A61K47/26;(IPC1-7):A61K31/66 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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