| 发明名称 |
Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration |
| 摘要 |
The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10° C. wherein R1 and L are as defined herein.
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| 申请公布号 |
US2002058670(A1) |
申请公布日期 |
2002.05.16 |
| 申请号 |
US20010987845 |
申请日期 |
2001.11.16 |
| 申请人 |
BIOCHEM PHARMA INC. |
发明人 |
MANSOUR TAREK;CIMPOIA ALEX;BEDNARSKI KRZYSZTOF |
| 分类号 |
C07D473/00;C07D317/10;C07D405/04;C07D473/04;C07D473/16;C07D473/18;C07D473/30;C07D473/32;C07D473/34;C07D473/40;C07D487/04;C07H;(IPC1-7):A61K31/522;A61K31/513 |
主分类号 |
C07D473/00 |
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