发明名称 |
IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS |
摘要 |
A class of 7-phenylimidazo [1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a - NH- linkage, being selective ligands for GABAA receptors, in particular having good affinity for the .alpha.2 and/or .alpha.3 and/or .alpha.5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
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申请公布号 |
CA2427779(A1) |
申请公布日期 |
2002.05.16 |
申请号 |
CA20012427779 |
申请日期 |
2001.11.08 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
SZEKERES, HELEN JANE;VAN NIEL, MONIQUE BODIL;RUSSELL, MICHAEL GEOFFREY NEIL;BETTATI, MICHELA;BLURTON, PETER;CARLING, WILLIAM ROBERT;LEWIS, RICHARD THOMAS;JENNINGS, ANDREW;HALLETT, DAVID JAMES;CHAMBERS, MARK STUART;STREET, LESLIE JOSEPH |
分类号 |
A61K31/53;A61P25/00;A61P25/22;C07D487/04;(IPC1-7):C07D487/04;C07D235/00;C07D253/00 |
主分类号 |
A61K31/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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