USE OF THE HUMAN LRP/MVP PROMOTOR FOR A VECTOR THAT CAN BE INDUCED BY THERAPY

摘要

The invention relates to a vector system which can be regulated by therapy, using the gene promoter of the human lung resistance protein (LRP/MVP). This vector system for the expression, inducible by therapy, of therapeutically relevant genes in mammal cells is to be applied in the pharmaceutical industry and in medicine. The aim of the invention is to regulate tumour gene therapy with therapeutic modalities such as chemotherapy or hyperthermy for the duration of these therapies, to ensure that such gene therapy with chemotherapy, hyperthermy and other means results in a controlled, more efficient treatment of the tumour disease. An essential feature of the invention is a vector which can be induced by therapy, for the expression of therapeutic genes based on vector base structures that are suitable for expression in mammal cells. The vector is characterised by a human LRP/MVP promotor or a defined sequence thereof which can be induced by chemotherapy, hyperthermy and with other agents and a gene which codes for a therapeutic protein or non-translated RNA.