METHOD OF PRODUCING ANTIBODIES BY IMMUNIZATION WITH CONJUGATES OF MOLECULES COUPLED TO CHARGE-MODIFIED PROTEINS

摘要

A method for raising antibodies against molecules, particularly molecules with low immunogenicity, by coupling the molecule to a carrier containing a balanced charge mixture of proteins is provided. Also provided are antibodies and immunoassays containing antibodies raised in accordance with these methods. Pharmaceutical compositions containing these antibodies or a part thereof and methods of using these compositions to treat various diseases and infections are also provided. In addition, vaccines containing an antibody or an immunogenically stimulatory amount of a molecule coupled to the carrier of a balanced charge mixture of proteins and methods of inducing an immune response in an animal against the molecule by administration of these vaccines are provided.