发明名称 |
METHOD OF IDENTIFYING MODULATORS OF PRESENILIN |
摘要 |
A method of identifying a modulator of presenilin function, the method comprising: (i) providing (a) a polypeptide capable of binding a presenilin, which polypeptide comprises the amino acid sequence of SEQ ID NO: 1 or a functional variant thereof, or a fragment of either thereof which is capable of binding to presenilin; (b) a presenilin or a variant thereof or a fragment of either thereof capable of binding to a polypeptide which comprises the amino acid sequence of SEQ ID NO: 1; (c) a test substance under conditions that would permit binding of a polypeptide (a) to a presenilin (b) in the absence of the test substance; (ii) monitoring presenilin mediated activity; and (iii) determining thereby whether the test substance is a modulator of presenilin activity, a modulator identified by a method of the invention and use of a modulator identified by a method of the invention in the treatment of Alzheimer's disease.
|
申请公布号 |
WO0167097(A3) |
申请公布日期 |
2002.05.16 |
申请号 |
WO2001GB01059 |
申请日期 |
2001.03.09 |
申请人 |
GLAXO GROUP LIMITED;HALE, RICHARD, STEPHEN;ROWLEY, ADELE;BLACKSTOCK, WALTER |
发明人 |
HALE, RICHARD, STEPHEN;ROWLEY, ADELE;BLACKSTOCK, WALTER |
分类号 |
G01N33/68;(IPC1-7):G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|