发明名称 |
SPHINGOMYELINASE ENZYMES AND USES RELATING THERETO |
摘要 |
Two novel sphingomyelinases are provided, having optimum activities at pH7 and pH8, respectively. The two proteins have different tissue sources, the pH7 form from e.g. T cell lymphomas, and the pH8 form from e.g. B cell lymphomas. Methods of treatment and diagnosis, fragments, antibodies, nucleic acids and pharmaceutical compositions are also provided.
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申请公布号 |
WO0166709(A3) |
申请公布日期 |
2002.05.16 |
申请号 |
WO2001GB00998 |
申请日期 |
2001.03.06 |
申请人 |
CANCER RESEARCH VENTURES LIMITED;DENISON, CHRISTOPHER, MARCUS;AMTMANN, EBERHARD;CHLICHLIA, KATHERINI |
发明人 |
AMTMANN, EBERHARD;CHLICHLIA, KATHERINI |
分类号 |
A61K38/00;C12N9/16;C12N15/55;(IPC1-7):C12N9/16;C07K16/40;A61K38/17;C12Q1/34;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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