摘要 |
The present invention relates to diazafluorenone derivatives of Formula I which are IL-8 receptor antagonists useful as pharmaceutical agents, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treating a chemokine-mediated disease state in a mammal, including a human. The diazafluorenones of the present invention are useful in the treatment of chemokine-mediated diseases such as, psoriasis, cancer, asthma, Alzheimer's disease, inflammatory bowel disease, graft versus host reaction, or allograft rejections in a mammal, including a human. |
申请人 |
WARNER-LAMBERT COMPANY;BRATTON, LARRY, DON;CONNOR, DAVID, THOMAS;MILLER, STEVEN, ROBERT;TRIVEDI, BHARAT, KALIDAS;UNANGST, PAUL, CHARLES |
发明人 |
BRATTON, LARRY, DON;CONNOR, DAVID, THOMAS;MILLER, STEVEN, ROBERT;TRIVEDI, BHARAT, KALIDAS;UNANGST, PAUL, CHARLES |