发明名称 |
INHIBITORS OF COPPER-CONTAINING AMINE OXIDASES |
摘要 |
The present invention is directed to hydrazino compounds that functions as inhibitors of copper-containing amine oxidases commonly known as semicarbazidesensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatorses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R<1> to R<8> and X are as defined herein. |
申请公布号 |
WO0202090(A3) |
申请公布日期 |
2002.05.16 |
申请号 |
WO2001FI00638 |
申请日期 |
2001.07.04 |
申请人 |
BIOTIE THERAPIES CORP.;SMITH, DAVID, JOHN;JALKANEN, MARKKU;FUELOEP, FERENC;LAZAR, LASZLO;SZAKONYI, ZSOLT;BERNATH, GABOR |
发明人 |
SMITH, DAVID, JOHN;JALKANEN, MARKKU;FUELOEP, FERENC;LAZAR, LASZLO;SZAKONYI, ZSOLT;BERNATH, GABOR |
分类号 |
C07D217/16;A61K31/00;A61K31/131;A61K31/14;A61K31/15;A61K31/40;A61K31/445;A61K31/472;A61K31/5395;A61P1/04;A61P1/16;A61P3/00;A61P3/10;A61P9/00;A61P9/10;A61P11/06;A61P17/00;A61P19/02;A61P25/00;A61P29/00;A61P37/00;A61P43/00;C07B61/00;C07D273/04;C07D498/04;C07D498/10 |
主分类号 |
C07D217/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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