摘要 |
he present invention is directed to compounds represented by the following structural formula (I'), and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-2-alkyl, heteroaryl-C0-2-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy. Additionally, R4 is H, halo, a substituted or unsubstituted group selected from C1-C5 alkyl, C1-C5 alkoxy, C3-C6 cycloalkyl, arylC0-C4alkyl and phenyl, or R3 and R4 are combined to form a C3-C4 cycloalkyl. |
申请人 |
ELI LILLY AND COMPANY;MANTLO, NATHAN, BRYAN;COLLADO CANO, IVAN;DOMINIANNI, SAMUEL, JAMES;ETGEN, GARRET, JAY, JUNIOR;GARCIA-PAREDES, CRISTINA;JOHNSTON, RICHARD, DUANE;LETOURNEAU, MICHAEL, EDWARD;MARTINELLI, MICHAEL, JOHN;MAYHUGH, DANIEL, RAY;SAEED, ASHRAF;THOMPSON, RICHARD, CRAIG;WANG, XIADONG;COFFEY, DAVID, SCOTT;SCHMID, CHRISTOPHER, RANDALL;VICENZI, JEFFREY, THOMAS;XU, YANPING |
发明人 |
MANTLO, NATHAN, BRYAN;COLLADO CANO, IVAN;DOMINIANNI, SAMUEL, JAMES;ETGEN, GARRET, JAY, JUNIOR;GARCIA-PAREDES, CRISTINA;JOHNSTON, RICHARD, DUANE;LETOURNEAU, MICHAEL, EDWARD;MARTINELLI, MICHAEL, JOHN;MAYHUGH, DANIEL, RAY;SAEED, ASHRAF;THOMPSON, RICHARD, CRAIG;WANG, XIADONG;COFFEY, DAVID, SCOTT;SCHMID, CHRISTOPHER, RANDALL;VICENZI, JEFFREY, THOMAS;XU, YANPING |