ACID DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS

摘要

Compounds of formula I and II, or pharmaceutically-acceptable salts thereof , are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is a linker, and R1 R27, W, Z1 , and Z2 are as defined in the specification.