CARBOXYLIC ACID TYPE LIPID

摘要

A carboxylic acid type lipid which is a negatively charged lipid capable of stably donating negative charges to the surface of endoplasmic reticula without producing any side effect. It is represented by the following general formula [1]: [1] wherein R1, R2, and R3 each is a substituent, and one of these is represented by the general formula [X] [X] (wherein M is hydrogen or a monovalent cation and m, indicating the length of the methylene chain, is an integer of 1 to 5) and the remainder each is a chain hydrocarbon group; A1, A2, and A3 are the same or different and each is a group selected among C(O)O, CONH, and NHCO; and n, indicating the length of the methylene chain, is an integer of 1 to 3.