Permanently radially compressed column

摘要

An embodiment of the present invention features a chromatographic device. The chromatographic device comprises a body having a cylindrical wall having an exterior diameter. The cylindrical wall is flexible, expanding and contracting in response to radial pressure. The cylindrical wall defines a cavity for holding a chromatographic media. A chromatographic media is retained within said cavity. A spring element surrounds the cylindrical wall, permanently radially compressing said cylindrical wall and opposing the expansion of the wall in response to internal pressure within the cavity. The radial compression prevents the movement of the chromatographic media in the cavity and the opening of channels about the walls of the body.