发明名称 |
REAL-TIME, IN SITU BIOMANUFACTURING PROCESS MONITORING AND CONTROL IN RESPONSE TO IR SPECTROSCOPY |
摘要 |
A method and system for providing real-time, biomanufacturing process monitoring and control in response to infra-red (IR) spectroscopic fingerprinting of a biomolecule. IR spectroscopy is used to fingerprint an active biomolecule in situ in a biomanufacturing process. In one embodiment, Fourier Transform Infra-red spectroscopy (FTIR) is used to determine whether an active or aged biomolecule is present in stages of a biomanufacturing process. In one preferred example, the biomanufacturing process manufactures a biomaterial in bulk. The biomanufacturing process has four stages: bioproduction, recovery, purification, and bulk storage. FTIR spectroscopy is used to monitor the optimization of each process step by providing feedback controls, and to fingerprint in real-time, in situ whether active biomolecules are present in each stage. |
申请公布号 |
EP1204855(A1) |
申请公布日期 |
2002.05.15 |
申请号 |
EP20000950357 |
申请日期 |
2000.07.14 |
申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
NAUGHTON, RAYMOND, A.;ROHRER, THOMAS, R.;GENTZ, REINER, L. |
分类号 |
C12M1/36;C12P21/00;G01N21/35;G01N30/74;G01N30/88;(IPC1-7):G01N21/29 |
主分类号 |
C12M1/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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