METHOD FOR INTRODUCING A 1,2 DOUBLE BOND INTO AZASTEROIDS

摘要

A process for introducing a 1,2 double bond into a compound of the formula -i- which comprises the process of (a) treating the compound of formula I with oxalyl chloride; (b) brominating the product of step (a) followed by in situ dehydrobromination; (c) deprotecting the product of step (b) to yield the .alpha. and .beta. isomers; (d) dehydrobrominating the product of step (c), which results in the introduction of a double bond at the 1,2 position.