发明名称 |
Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use |
摘要 |
The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions comprising the same, and a method of using such sustained-release derivatives to bind the dopamine transporter to achieve a desired effect, such as antagonism of dopamine reuptake inhibitors, such as cocaine, or dopamine releasers or norepinephrine and/or serotonin reuptake inhibitors, such as methamphetamine.
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申请公布号 |
US6387389(B1) |
申请公布日期 |
2002.05.14 |
申请号 |
US19990269926 |
申请日期 |
1999.06.30 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
ROTHMAN RICHARD B.;RICE KENNER C.;LEWIS DAVID;MATECKA DOROTA;GLOWA JOHN R. |
分类号 |
C07D295/08;A61K31/495;A61K31/551;A61P25/30;A61P43/00;C07D215/26;C07D243/04;C07D295/084;C07D295/088;C07D307/52;C07D333/20;(IPC1-7):A61F13/00;C07D241/00;C07D401/00 |
主分类号 |
C07D295/08 |
代理机构 |
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主权项 |
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地址 |
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