| 发明名称 |
COMPOSITION CONTAINING MEDICINE WITH RETINOIC ACID RECEPTOR AGONIST EFFECT |
| 摘要 |
PROBLEM TO BE SOLVED: To obtain a composition stable in the solution or in the dissolution state of a medicine having a retinoic acid receptor agonist effect. SOLUTION: This composition is obtained by mixing poly (ethylene glycol), a basic additive and water with a medicine having a retinoic acid receptor agonist effect. The example of the above medicine is 4-[2- 5-(7-fluoro-4- trifluoromethylbenzofran-2-yl)pyrrolyl}]benzoic acid shown in formula 1 or etretinate expressed by formula 2. As the basic additive, a carboxylate such as sodium acetate and an inorganic salt such as sodium hydroxide are exemplified. |
| 申请公布号 |
JP2002138051(A) |
申请公布日期 |
2002.05.14 |
| 申请号 |
JP20000329938 |
申请日期 |
2000.10.30 |
| 申请人 |
EISAI CO LTD |
发明人 |
SUZUKI YASUYUKI |
| 分类号 |
C07D405/04;A61K31/192;A61K31/216;A61K31/40;A61K31/4427;A61K31/443;A61K31/4433;A61K45/00;A61K47/00;A61K47/04;A61K47/12;A61K47/34;A61P3/06;A61P3/10;A61P9/00;A61P13/00;A61P13/12;A61P15/00;A61P17/00;A61P19/00;A61P19/02;A61P19/10;A61P21/00;A61P21/04;A61P29/00;A61P31/00;A61P35/00;A61P35/02;A61P37/02;A61P43/00;C07D409/06 |
主分类号 |
C07D405/04 |
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