| 发明名称 |
Inhibitors of farnesyl protein transferase |
| 摘要 |
Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.
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| 申请公布号 |
US6387926(B1) |
申请公布日期 |
2002.05.14 |
| 申请号 |
US19980087179 |
申请日期 |
1998.05.29 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BHIDE RAJEEV S.;DING CHARLES Z.;HUNT JOHN T.;KIM SOONG-HOON;LEFTHERIS KATERINA |
| 分类号 |
C07D403/08;A61K31/4709;A61K31/55;A61P35/00;A61P37/02;A61P43/00;C07D233/54;C07D401/06;C07D401/14;C07D403/06;C07D403/12;C07D403/14;C07D409/14;(IPC1-7):A61K31/47;C07D215/00;C07D215/16;C07D215/20;C07D215/36 |
主分类号 |
C07D403/08 |
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