| 摘要 |
PURPOSE: A peptide for inhibiting HIV infection is provided, which peptide can inhibit the cell fusion of HIV, can be cheaply and easily prepared since it consists of 30 or less of amino acids, and does not need the additional modification for use. CONSTITUTION: The peptide for inhibiting HIV infection comprises an Helix-capping motif peptide capable of binding with 19 amino acids of C-terminal region(amino acids 628 to 646) of gp41 which is a cell membrane fusion protein of HIV, in which the Helix-capping motif peptide has the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 3; the 19 amino acids of C-terminal region of gp41 has the amino acid sequence selected from SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6; and the peptide for inhibiting the infection of HIV has the amino acid sequence selected from SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, and SEQ ID NO: 13.
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