A composition and methods thereof for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as metformin, on a once-a-day basis. The dosage form provides a mean time to maximum plasma concentration (Tmax) of the drug which occurs at 5.5 to 7.5 hours after oral administration on a one-a-day basis to human patients. Preferably, the dose of drug is administered at dinnertime to a patient in the fed state.
申请公布号
WO0236100(A1)
申请公布日期
2002.05.10
申请号
WO2001US48306
申请日期
2001.10.30
申请人
ANDRX CORPORATION;CHIH-MING, CHEN;XIU-XIU, CHENG;JAN, STEVE;CHOU, JOSEPH
发明人
CHIH-MING, CHEN;XIU-XIU, CHENG;JAN, STEVE;CHOU, JOSEPH