TRANSDERMAL DRUG DELIVERY SYSTEM WITH IMPROVED WATER ABSORBABILITY AND ADHESION PROPERTIES

摘要

The present invention relates to an adhesive based transdermal drug delivery system, having excellent water absorbability, comprising a backing film, an adhesive matrix containing active ingredients and a release liner which is peelable prior to use. The matrix layer of the present invention is a multilayered sandwich and comprises drug containing outer adhesive layers, adhering to the backing film and release liner respectively, between which is sandwiched an absorption enhancer layer. The adhesive layers comprise (a) an acrylate adhesive, (b) a mixture of high and low molecular weight polyvinylpyrrolidones, and (c) a colloidal silica.