METHOD OF PURIFICATION OF NEUROPEPTIDE CONTAINING VESICLES FROM THE BRAIN
摘要
The invention is directed to a new method of isolating and purifying a large quantity of neuropeptide containing secretory vesicles (dense core vesicles) from a specific brain region and subsequently isolating and identifying novel neuropeptides contained therein. The method of the invention has significant practical value. The availability of large quantities of such vesicles will enable the identification of novel peptides using highly sensitive techniques, e.g., mass spectroscopy. Such neuropeptides are highly likely to have novel biological effects.
申请公布号
WO0237104(A2)
申请公布日期
2002.05.10
申请号
WO2001US45485
申请日期
2001.10.31
申请人
THE TRUSTEES OF BOSTON UNIVERSITY;FINE, RICHARD, E.;BERG, ERIC, A.