| 摘要 |
<p>Organic vanadium complexes can be used for prevention and/or treatment of cerebral ischemia. The vanadium complex may be bis(N-octyl cysteine amide) oxovanadium (IV), bis(maltolato)oxovanadium (IV), bis(picolinato) oxovanadium (IV) or a vanadium complex of a hydroxamate, preferably of a monohydroxamate, and is more preferably a vanadium complex of a monohydroxamate of the formula R-CO-NHOH.X, wherein R is a residue selected from: (i) H2N-CH(COY)-(CH2)n-; (ii) H2N-CH(COOH)-CH2-S-CH2; and (iii) pyridyl, piperidyl or tetrahydroisoquinolinyl, wherein n is 1, 2 or 3, and Y is OH or NH2; and X is a vanadium compound selected from a vanadyl (VO2+), metavanadate (VO¿3?-) or vanadate (VO¿4?3-) salt.</p> |
