发明名称 |
PROTEIN COMPRISING IG-LIKE DOMAIN 4 OF A VEGF RECEPTOR MEDIATES RECEPTOR DIMERIZATION, BUT NOT ACTIVATION |
摘要 |
The invention relates to novel compounds that act to prevent dimerisation of vascular endothelial growth factor (VEGF) receptors. The novel compounds may comprise the amino acid sequence of the fourth Ig-like domain of a VEGF receptor, or a variant that retains the ability to bind to a VEGF receptor. These compounds are useful in the inhibition of the biological activity of VEGF receptors and may thus be used to treat diseases in which VEGF plays a role.
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申请公布号 |
WO0142284(A3) |
申请公布日期 |
2002.05.10 |
申请号 |
WO2000GB04693 |
申请日期 |
2000.12.07 |
申请人 |
METRIS THERAPEUTICS LIMITED;PAPPA, HELEN |
发明人 |
PAPPA, HELEN |
分类号 |
A61K38/00;C07K14/71;C12N15/12;(IPC1-7):C12N15/12;C12N15/10;C12N15/62;C12N15/66;C07K16/42;A61K38/18;A61K31/70 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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