发明名称 |
ACTIVE VARIANTS OF FGF WITH IMPROVED SPECIFICITY |
摘要 |
The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.
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申请公布号 |
CA2427477(A1) |
申请公布日期 |
2002.05.10 |
申请号 |
CA20012427477 |
申请日期 |
2001.10.18 |
申请人 |
PROCHON BIOTECH LTD. |
发明人 |
BOGIN, OREN;ADAR, RIVKA;YAYON, AVNER |
分类号 |
C07K14/50;(IPC1-7):C12N15/12;A61K38/18;A61P19/00;A61P35/00;C12N15/63 |
主分类号 |
C07K14/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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