| 摘要 |
<p>The present invention provides cell lines expressing one or more recombinant peripheral nerve (PN) sodium channels, preferably a human PN sodium channel. The invention also provides methods for preparing said cell lines. The invention furthermore pertains to the use of said cell lines for the identification of PN sodium channel agonists, antagonists or modulators and methods for the identification of said agonists, antagonists or modulators. The invention also provides pharmaceutical compositions comprising said agonists, antagonists or modulators. The invention furthermore is concerned with the use of agonists, antagonists or modulators in the manufacture of a medicament for the treatment of chronic pain disorders.</p> |
