ANTI-HIV-1 CONJUGATES FOR TREATMENT OF HIV DISEASE

摘要

The present invention provides a conjugate of an anti-CD4 molecule and an antichemokine receptor molecule. These molecules may be antibodies. The anti-CD4 molecule may be an antibody that inhibits HIV-1 infection of CD4+ cells and also inhibits syncytia formation between CD4+ cells, but does not cause immunosuppression in humans. The anti-chemokine receptor antibody may be an anti-CCR5 molecule. The invention also provides for conjugate of an anti-CD4 molecule and an HIV-1 fusion inhibiting peptide. Both types of conjugates may be formed by chemical methods and may or may not include a linker. Numerous types of linkers may be used. Both types of conjugates may also be expressed as recombinant proteins with or without linkers. The invention also provides a method of treating HIV-1 disease by providing a conjugate to a subject. The conjugate may be provided by providing the subject with a recombinant nucleic acid in a viral vector.