发明名称 |
Nocathiacin antibiotics prepared by biotransformation or chemical methods |
摘要 |
Novel nocathiacin derivatives have been prepared by both biotransformation and chemical methods. A novel nocathiacin derivative, nocathiacin IV, was prepared by either incubation of protease from Streptomyces griseus (Sigma, Cat# P5147) with nocathiacin I in DMF or by chemical methods. Fermentation of Actinoplanes sp. ATCC 53771 in the presence of nocathiacin IV produces a new compound nocathiacin IV 6-deoxyglucoside. Both nocathiacin IV and nocathiacin IV 6-deoxyglucoside have broad spectrum antibiotic activity against Gram-positive bacteria and have in vivo efficacy in animals.
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申请公布号 |
US2002055465(A1) |
申请公布日期 |
2002.05.09 |
申请号 |
US20010919455 |
申请日期 |
2001.07.31 |
申请人 |
LI WENYING;LEET JOHN;HUANG XIAOHUA;LAM KIN SING;REGUEIRO-REN ALICIA |
发明人 |
LI WENYING;LEET JOHN;HUANG XIAOHUA;LAM KIN SING;REGUEIRO-REN ALICIA |
分类号 |
C07D513/22;C07H17/00;C07H17/02;C07H17/08;(IPC1-7):A61K38/14;C07K9/00;A61K31/70 |
主分类号 |
C07D513/22 |
代理机构 |
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