Soluble support for organic synthesis

摘要

Polymer supports for liquid-phase organic synthesis (LPOS) are employed in a process for transferring a chemical intermediate between immiscilbe solvents. These compounds are produced with an expanded range of solubility range in a variety of solvent systems. A sequence of normal and "living" free radical polymerizations are employed to generate a library of block copolymers possessing either block or graft architecture with initiators 100, 200 and 3-4 and a diverse set of vinyl monomers 5-9. Novel bifunctional initiators are employed that have functional groups that independently produce free radical polymerizations to produce the block copolymers. Preferred functional groups include diazene (-N=N-) and 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) moieties tethered by ester or ether linkages.