发明名称 |
Test for linkage and association in general pedigrees: the pedigree disequilibrium test |
摘要 |
The present invention provides a method for the analysis of linkage disequilibrium between at least one marker locus and a disease or trait locus of interest. The method comprises the steps of: (a) providing a data set comprising a marker locus with at least two alleles for a plurality of extended pedigrees (e.g., plant pedigrees, animal pedigrees), where N is the number of unrelated extended pedigrees, at least one of said extended pedigrees containing at least one informative nuclear family or informative discordant sibship; then (b) determining a random variable XT for each triad within an informative nuclear family for each allele Mi; (c) determining a random variable XS for each DSP within an informative discordant sibship for each allele M1; (d) determining a summary random variable D from XS and XT for each of said extended pedigrees for each allele M1; and then (e) determining a statistic T from each of said summary random variables D from each of said N unrelated extended pedigrees for each allele Mi. An extreme (large or small) value for T indicates greater linkage disequilibrium.
|
申请公布号 |
US2002055821(A1) |
申请公布日期 |
2002.05.09 |
申请号 |
US20010767453 |
申请日期 |
2001.01.23 |
申请人 |
MARTIN EDEN R.;KAPLAN NORMAN L. |
发明人 |
MARTIN EDEN R.;KAPLAN NORMAN L. |
分类号 |
G06F19/00;(IPC1-7):G06F19/00;C12Q1/68 |
主分类号 |
G06F19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|