发明名称 |
MICROFLUIDIC DEVICES FOR THE CONTROLLED MANIPULATION OF SMALL VOLUMES |
摘要 |
<p>A method for conducting a broad range of biochemical analyses or manipulations on a series of nano- to subnanoliter reaction volumes and an apparatus for carrying out the same are disclosed. The invention is implemented on a fluidic microchip to provide high serial throughput. In particular, the disclosed device is a microfabricated channel device that can manipulate nanoliter or subnanoliter reaction volumes in a controlled manner to produce results at rates of 1 to 10 Hz per channel. The reaction volumes are manipulated in serial fashion analogous to a digital shift register. The invention has application to such problems as screening molecular or cellular targets using single beads from split-synthesis combinatorial libraries, screening single cells for RNA or protein expression, genetic diagnostic screening at the single cell level, or performing single cell signal transduction studies.</p> |
申请公布号 |
EP1202802(A1) |
申请公布日期 |
2002.05.08 |
申请号 |
EP20000967377 |
申请日期 |
2000.08.10 |
申请人 |
UT-BATTELLE, LLC |
发明人 |
RAMSEY, J., MICHAEL;JACOBSON, STEPHEN, C. |
分类号 |
G01N27/447;B01D57/02;B01F5/04;B01F13/00;B01J4/00;B01J19/00;B01J19/32;B01L3/00;B03C5/00;F15C5/00;F16K99/00;G01N35/08;G01N37/00;G11C19/00;G11C25/00;(IPC1-7):B01L3/00 |
主分类号 |
G01N27/447 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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