发明名称 |
Genes for the biosynthesis of epothilones |
摘要 |
Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.
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申请公布号 |
US6383787(B1) |
申请公布日期 |
2002.05.07 |
申请号 |
US20000567899 |
申请日期 |
2000.05.10 |
申请人 |
NOVARTIS AG |
发明人 |
SCHUPP THOMAS;LIGON JAMES MADISON;MOLNAR ISTVAN;ZIRKLE ROSS;CYR DEVON DAWN;GOERLACH JOERN |
分类号 |
C07K14/195;C12N1/21;C12P17/18;(IPC1-7):C12N9/00;C12N9/10;C07H21/04 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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