发明名称 |
Method of identifying compounds capable of activating ISL production |
摘要 |
The present invention is directed to an Immunodeficiency-virus Suppressing Lymphokine (ISL) produced by stimulated CD8+ PBMC, cloning and isolation of nucleic acid molecules for eukaryotic ISL, and methods of treating viral infections with ISL. ISL is able to suppress the replication of viruses, especially retroviruses, in vitro and in vivo. More, specifically, a method is described for detecting a compound capable of inducing the expression of ISL by measuring the presence of ISL and the ability of ISL to inhibit HIV transcription.
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申请公布号 |
US6383739(B1) |
申请公布日期 |
2002.05.07 |
申请号 |
US19990353362 |
申请日期 |
1999.07.15 |
申请人 |
BUDESREPUBLIK DEUTSCHLAND VERTRETEN DURCH DEN BUNDESMINISTER |
发明人 |
KURTH REINHARD;BAIER MICHAEL;METZNER KARIN;WERNER ALBRECHT |
分类号 |
G01N33/53;A61K38/00;A61K48/00;A61P31/12;A61P35/00;A61P37/04;C07K14/52;C07K14/54;C07K16/24;C12N1/21;C12N5/10;C12N15/09;C12N15/19;C12P21/02;C12Q1/68;G01N33/569;(IPC1-7):C12Q1/70;C12Q3/00;C12Q1/00;G01N33/567 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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