COMPOUNDS WHICH ARE SELECTIVE ANTAGONISTS OF THE HUMAN NK3 RECEPTOR AND THEIR USE AS MEDICINAL PRODUCTS AND DIAGNOSTIC TOOLS

摘要

A compound of formula: (see formula I) in which: - Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a ( C1-C4) alkoxy; - R1 represents a methyl group; - R11 represents hydrogen; - or R1 and R11 together represent a -(CH2)3- group; - R2 represents a hydroxyl; a (C1-C7)alkoxy; a (C1-C7)acyloxy; a cyano; an -NR6R7 group; an -NR3COR4 group; an -NR3COOR8 group; an -NR3SO2R9 group; an -NR3CONR10R12 group; a (C1-C7)acyl group: a (C1- C7)alkoxycarbonyl; a -CONR10R12 group: a -CH2OH group; a (C1-C7)alkoxymethyl; a (C1-C7)acyloxymethyl; a (C1- C7)alkylaminocarbonyloxymethyl; a -CH2NR13R14 group; a -CH2NR3COR4 group; a -CH2NR3COOR8 group; a -CH2NR3SO2R9 group; a -CH2NR3CONR10R12 group; or R2 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; - or Ar and R2, together with the carbon atom to which they are attached, constitute a group of formula: (see formula II) Application: NK3 antagonists