PLATELET-SPECIFIC CHIMERIC IMMUNOGLOBULIN

摘要

Platelet-specific, chimeric immunoglobulin and immunoglobulin fragments are described. The chi- meric molecules are made up of a nonhuman antigen binding region and a human constant region. Prefer- red immunoglobulins are specific for glycoprotein IIb/IIIa receptor in its complexed form; they block ligand binding to the receptor and prevent. platelet aggregation. The immunoglobulins are useful in anti-thrombotic therapy alone or in conjunction with thrombolytic agents and in thrombus imaging.