发明名称 |
Identification and modification of immunodominant epitopes in polypeptides |
摘要 |
The invention provides for methods of modifying immunodominant epitopes on polypeptides, preferably polypeptides intended for therapeutic use. Knowledge of immunodominant epitopes prior to clinical use of polypeptides would be useful to design and engineer less immunogenic molecules. The invention provides for methods of identifying immunodominant epitopes and modifying an immunodominant epitope to reduce the immune response to the polypeptide while still retaining a substantial therapeutic activity of the polypeptide. The modified polypeptides are useful therapeutically. |
申请公布号 |
AU4575602(A) |
申请公布日期 |
2002.05.06 |
申请号 |
AU20020045756 |
申请日期 |
2001.06.04 |
申请人 |
GENENTECH, INC. |
发明人 |
EUGEN KOREN;JOHN, HOK, NIN LOWE |
分类号 |
A61K38/00;A61P7/00;C07K16/24;C12P21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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