| 摘要 |
Described are mammalian stem cells derived from somatic stem cells of a lower relative potency, pluripotent stem cells are obtained from somatic stem cells of lower relative potency. Also described are mammalian stem cell lines that are capable of stable regeneration in vitro, which cell lines are derived from lower relative potency somatic stems cells. In addition, methods are provided for the production of mammalian stem cells, cell lines and non-human mammals derived from somatic stem cells of a lower relative potency. The invention also provides methods for reprogramming a nucleus of a somatic cell so as to become a less differentiated stem cell. |
