发明名称 |
Verfahren zur Identifizierung von Verbindungen zur Hemmung von neoplastischen Veränderungen |
摘要 |
There is disclosed a pharmaceutical composition for the treatment of neoplasia, comprising a pharmaceutically acceptable carrier and a compound selected by: determining the cyclooxyegenase (COX) inhibitory activity of the compound; determining the PDE inhibition activity of the compound wherein the PDE is characterized by: (a) cGMP specificity over cAMP; (b) positive cooperative kinetic behaviour in the presence of cGMP substrate; (c) submicromolar affinity for cGMP; and (d) insensitivity to incubation with purified cGMP-dependent protein kinase; and selecting the compound that has COX inhibitory activity lower than said PDE activity for treating neoplasia. Also provided by the invention is a method for selecting a compound the treatment of neoplasia, comprising determining the cyclooxygenase (COX) inhibitory activity of the compound; determining the PDE2 inhibition activity of the compound; and selecting the compound that has COX inhibitory activity lower than said PDE activity for treating neoplasia. |
申请公布号 |
DE69901082(D1) |
申请公布日期 |
2002.05.02 |
申请号 |
DE1999601082 |
申请日期 |
1999.10.14 |
申请人 |
CELL PATHWAY, INC. |
发明人 |
LIU, LI;ZHU, BING;HAN, LI;THOMPSON, JOSEPH W.;PAMUKEU, RIFAT;PIAZZA, GARY A. |
分类号 |
A61K35/12;A61K31/00;A61K31/135;A61K31/165;A61K31/19;A61K31/192;A61K31/195;A61K31/365;A61K31/41;A61K31/4192;A61K38/00;A61K38/06;A61K38/46;A61K45/00;A61P35/00;A61P43/00;C12N9/16;C12Q1/26;C12Q1/44;G01N33/15;G01N33/50;G01N33/566;G01N33/574 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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