Patterned surfaces for bioconjugation and their preparation

摘要

The invention relates to a method for the large scale production of patterned active surfaces for bioconjugation comprising the steps of: (a) preparing a self-supporting film of a polyfunctional polymer network comprising an assembly of cross-linked polymer subchains, wherein each polymer subchain comprises a multitude of identical or different repeating units carrying one or more functional groups which allow an interaction of the polymer with one or more probe molecules, (b) providing said self-supporting film with patterned arrays of said one or more probe molecules via an interaction with said functional groups, (c) fixing said self-supporting film on a solid surface. In a preferred embodiment of the invention the patterned active surface obtained is cut into an endless tape of a desired format and wind-up onto a drum. This "endless chip" is ready for fixing it to a solid surface of any material or shape.