Preparation of thiazoles

摘要

There are described a process for the preparation of a compound of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="15" wi="55" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein
<DefinitionList compact="compact" id="dla01"><DefinedTerm>R</DefinedTerm><DefinitionDescription>is unsubstituted or substituted C<Sub>1</Sub>-C<Sub>12</Sub>alkyl, C<Sub>2</Sub>-C<Sub>4</Sub>alkenyl, C<Sub>2</Sub>-C<Sub>4</Sub>alkynyl, C<Sub>3</Sub>-C<Sub>6</Sub>cycloalkyl, aryl, heteroaryl or -SR<Sub>1</Sub>;</DefinitionDescription><DefinedTerm>R<Sub>1</Sub></DefinedTerm><DefinitionDescription>is unsubstituted or substituted C<Sub>1</Sub>-C<Sub>12</Sub>alkyl, C<Sub>1</Sub>-C<Sub>4</Sub>alkenyl, C<Sub>2</Sub>-C<Sub>4</Sub>alkenyl, C<Sub>2</Sub>-C<Sub>4</Sub>alkynyl, cycloalkyl, aryl or heteroaryl; and X is a leaving group; which comprises</DefinitionDescription></DefinitionList><UnorderedLists id="ula01" listStyle="none" compact="compact"><ListItem>a) reacting a compound of the formula
<Chemistry id="chema02" num="0002"><Image id="ia02" he="22" wi="64" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein R is as defined above, with a water-removing agent; or</ListItem><ListItem>b) for the preparation of a compound (I) wherein X is halogen or a sulfonate, reacting a compound of the formula
<Chemistry id="chema03" num="0003"><Image id="ia03" he="16" wi="65" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein R is as defined for formula (I), with a halogenating agent or a sulfonylating agent; or</ListItem><ListItem>c) for the preparation of a compound (I) wherein X is halogen, reacting a compound
<Chemistry id="chema04" num="0004"><Image id="ia04" he="18" wi="69" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein R is as defined for formula (I); and
<UnorderedLists id="ula02" listStyle="none" compact="compact"><ListItem>R<Sub>2</Sub> and R<Sub>3</Sub> are for example, H, C<Sub>1</Sub>-C<Sub>6</Sub>alkyl, C<Sub>3</Sub>-C<Sub>6</Sub>cycloalkyl, phenyl or benzyl;
with a compound of the formula halogen-C(=O)-O-C<Sub>1</Sub>-C<Sub>8</Sub>alkyl, halogen-C(=O)-O-aryl or halogen-C(=O)-O-benzyl;</ListItem><ListItem>intermediates for the preparation of the compounds (II) to (IV) and (VI) and a method for the preparation thereof.</ListItem></UnorderedLists></ListItem></UnorderedLists>