CATIONIC LIPID COMPOUNDS AND USE THEREOF FOR TRANSFERRING NEGATIVELY CHARGED SUBSTANCES OF THERAPEUTIC INTEREST

摘要

The invention concerns the use of a monocationic lipid compound of general formula I(A): R1O-CO-NH-(CH2)n-N<+>(C2H5)3, I<-> wherein: R1 represents the cholesteryl radical; n represents an integer equal to 1, 2 or 3 and in particular 3- beta [N-(N',N',N'-triethylaminopropane iodide)-carbamoyl] cholesterol (TEAPC-Chol) and/or a monocationic lipid compound of general formula I(B): R2-CO-NH-(CH2)n-N<+>(R)3,X<-> wherein: R2 represents in particular the abietic acid radical, or the radical of a derivative of cholanic (cholic, deoxycholic, dehydrocholic, lithocholic) acid; R represents in particular a methyl or ethyl radical; n represents an integer equal to 2 or 3; X represents in particular a chlorine or iodine atom; and/or a dicationic lipid compound of general formula II(A): R1O-CO-N[CH2- CH2-N<+>(R)3,X<->]2; and/or a dicationic lipid compound of general formula II(B): R1O-CO-CH2-CH2-CO-N[CH2-CH2-N<+>(R)3, X<->]2; and/or a dicationic lipid compound of formula II(C): R2-CO-N[CH2-CH2-N<+>(R)3,X<->]2 wherein R1 represents the cholesteryl radical; R2 represents in particular the abietic acid radical or the radical of a derivative of a cholanic (cholic, deoxycholic, dehydrocholic, lithocholic) acid; R represents in particular a hydrogen atom, a methyl or ethyl radical; X represents in particular a chlorine or iodine atom. Said compounds are useful for transfecting living organisms in vivo, organs in vivo, tumours in vivo, or cells in vitro or ex vivo.