发明名称 Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
摘要 The invention relates to compounds of general formula I <paragraph lvl="0"><in-line-formula>Ar-(L-K)n </in-line-formula>in which K means a cyclic non-radioactive metal complex of the DOTA-type, L means a linker, Ar means an aromatic radical, which contains a polycondensated aromatic hydrocarbon, and n means the numbers 1 or 2, diagnostic agents that contain these compounds, their use for MR imaging of necrosis and infarction as well as process for the production of these compounds and agents.
申请公布号 US2002052354(A1) 申请公布日期 2002.05.02
申请号 US20010759364 申请日期 2001.01.16
申请人 SCHERING AG 发明人 PLATZEK JOHANNES;SCHMITT-WILLICH HERIBERT;NIEDBALLA ULRICH;WEINMANN HANNS-JOACHIM;EBERT WOLFGANG
分类号 A61K31/555;A61K38/00;C07D257/02;C07F5/00;C07K5/02;(IPC1-7):A61K31/555;C07F19/00 主分类号 A61K31/555
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