发明名称 |
Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction |
摘要 |
The invention relates to compounds of general formula I <paragraph lvl="0"><in-line-formula>Ar-(L-K)n </in-line-formula>in which K means a cyclic non-radioactive metal complex of the DOTA-type, L means a linker, Ar means an aromatic radical, which contains a polycondensated aromatic hydrocarbon, and n means the numbers 1 or 2, diagnostic agents that contain these compounds, their use for MR imaging of necrosis and infarction as well as process for the production of these compounds and agents.
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申请公布号 |
US2002052354(A1) |
申请公布日期 |
2002.05.02 |
申请号 |
US20010759364 |
申请日期 |
2001.01.16 |
申请人 |
SCHERING AG |
发明人 |
PLATZEK JOHANNES;SCHMITT-WILLICH HERIBERT;NIEDBALLA ULRICH;WEINMANN HANNS-JOACHIM;EBERT WOLFGANG |
分类号 |
A61K31/555;A61K38/00;C07D257/02;C07F5/00;C07K5/02;(IPC1-7):A61K31/555;C07F19/00 |
主分类号 |
A61K31/555 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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