Synthesis of taxol, taxol analogs and their intermediates with variable a-ring side chain structures and compositions thereof

摘要

The present invention relates to chemical compounds that are useful in the production of taxanes. The chemical compounds according to the present invention have a generalized formula: wherein R1 is +NH3X- where X is deprotonated organic acid such as deprotonated trifluoroacetic acid, and wherein R2 may be acetyl or hydrogen, and P1 may be hydrogen or a hydroxyl protecting group, such as benzyloxymethyl.