| 摘要 |
Novel sulfate ester agents and the use of those agents for treating gastroesophageal reflux disease (GERD) are described, exemplary agents being of the formula: wherein X is -OCH2- or -CH2O-; Y is a group pendant from X comprising at least one -OSO3R4 moiety, wherein R4 is H or a pharmaceutically acceptable cation; n is an integer from 1-3; and R1 and R2 are each independently selected from the group consisting of -H, a halogen with an atomic number from 9 to 53, -SO3R4, -NCS, -NCO, -NH(CO)-OR3, -NH(CS)SR3, -NH(C=NH)OR3, -NHCOCH2Cl, -NHCOCH2Br, -NHCO-CH=CH2, -NHC(O)-CF3, wherein R4 is H or a pharmaceutically acceptable cation.
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