| 摘要 |
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (fr om 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation o f a carbon acid having a pKa less than about 25, is useful as an NO donor. Whe n the compound is obtained from a carbon acid with a pKa less than about 10, i t provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to 20, vascular relaxing effect is obtained at nanomol ar concentrations without glutathione. In another embodiment, a biocompatible polymer incorporates a C-nitroso moiety.
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