发明名称 Method for treatment of malignant neoplasms and a complex preparation having antimalignant activity
摘要 Use: medicine, oncology in particular. Technical object: simplification of the known method, lowering of the doses of injectable medicines and reducing the costs of treatment. Essence of the invention Depending on the character and seriousness of the disease, to a patient, together with the basic infusion-detoxication therapy, the complex preparation, comprising AFP in an amount of 0.07-0.15 mg, a polyene antibiotic, mainly amphotericin B or nystatin, in an amount of 4.2-7.0 mg and a filler, is parenterally injected once within twenty-four hours at an interval of three days in a course of 10 infusions. The complex preparation having antineoplastic activity comprises the following components, in mg: <table-cwu id="TABLE-US-00001"> <number>1</number> <table frame="none" colsep="0" rowsep="0"> <tgroup align="left" colsep="0" rowsep="0" cols="3"> <colspec colname="OFFSET" colwidth="35PT" align="left"/> <colspec colname="1" colwidth="63PT" align="left"/> <colspec colname="2" colwidth="119PT" align="center"/> <thead> <row> <entry></entry> <entry></entry> </row> <row> <entry></entry> <entry namest="OFFSET" nameend="2" align="center" rowsep="1"></entry> </row> </thead> <tbody valign="top"> <row> <entry></entry> <entry>AFP</entry> <entry>0.07-0.15</entry> </row> <row> <entry></entry> <entry>a polyene antibiotic</entry> <entry>4.2-7.0</entry> </row> <row> <entry></entry> <entry>a filler</entry> <entry>3.5-5.0</entry> </row> <row> <entry></entry> <entry namest="OFFSET" nameend="2" align="center" rowsep="1"></entry> </row> </tbody> </tgroup> </table> </table-cwu> As a filler polysaccharide from the group of rheopolyglykine, polyglykine, or sugar, e.g. glucose is mainly used. Positive effect: Simplification of the method, lowering of the doses of injectable medicines and reducing the costs of treatment. The complex preparation distinguishes by high efficiency of antineoplastic activity, a small number of components, simplicity of preparation and a long term of storage.
申请公布号 US2002051778(A1) 申请公布日期 2002.05.02
申请号 US20010885645 申请日期 2001.06.20
申请人 PAK VLADIMIR NIKOLAEVICH;PAK NATALIA ANATOLIEVNA;STEPANOVICH SERGEI;NIKONOV SERGEI DANILOVICH;OGIRENKO ANATOLI PAVLOVICH 发明人 PAK VLADIMIR NIKOLAEVICH;PAK NATALIA ANATOLIEVNA;STEPANOVICH SERGEI;NIKONOV SERGEI DANILOVICH;OGIRENKO ANATOLI PAVLOVICH
分类号 A61K38/17;A61P35/00;(IPC1-7):A61K38/48;A61K31/715;A61K31/704 主分类号 A61K38/17
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