发明名称 |
IN SITU BIOPROSTHETIC FILLER AND METHODS, PARTICULARLY FOR THE IN SITU FORMATION OF VERTEBRAL DISC BIOPROSTHETICS |
摘要 |
Bioprosthetic devices (10) include an exterior biological tissue member (10-1) which at least partly defines a cavity, and a proteinaceous biopolymer (10-2) which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device (10) is a bioprosthetic vertebral disc, having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer (10-2). Preferably, the proteinaceous biopolymer (10-2) is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity. |
申请公布号 |
WO0234111(A2) |
申请公布日期 |
2002.05.02 |
申请号 |
WO2001US32632 |
申请日期 |
2001.10.24 |
申请人 |
CRYOLIFE, INC.;YUKSEL, K., UMIT;WALSH, STEVEN, P.;BLACK, KIRBY, S. |
发明人 |
YUKSEL, K., UMIT;WALSH, STEVEN, P.;BLACK, KIRBY, S. |
分类号 |
A61L27/00;A61F2/44;A61L27/18;A61L27/22;A61L27/36;A61L27/40 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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