| 发明名称 |
N-LINKED SULFONAMIDES OF HETEROCYCLIC THIOESTERS |
| 摘要 |
This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity. |
| 申请公布号 |
EP0957913(A4) |
申请公布日期 |
2002.05.02 |
| 申请号 |
EP19970950991 |
申请日期 |
1997.12.22 |
| 申请人 |
GPI NIL HOLDINGS, INC. |
发明人 |
HAMILTON, GREGORY, S.;LI, JIA-HE;HUANG, WEI |
| 分类号 |
A61K31/40;A61K31/445;A61K31/4453;A61K31/47;A61K31/472;A61K31/495;A61K31/54;A61K31/55;A61K31/553;A61K31/554;A61P25/00;A61P25/02;A61P25/16;A61P25/28;A61P31/18;A61P43/00;C07D;C07D207/46;C07D207/48;C07D211/96;C07D215/58;C07D217/12;C07D223/06;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D473/00 |
主分类号 |
A61K31/40 |
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